Endocrine Abstracts

Aim: Given the aggressive biological features of metastatic prostate cancer, a more aggressive treatment with [177Lu]-PSMA might be appropriate.Materials and methods: We have treated 15 patients (mean age 69 years) with intended 3 cycles of [177Lu]-PSMA every 4 weeks. All patients have been examined with [68Ga]-PSMA PET/MRI to validate PSMA expression of all metastatic lesions. We monitored haemoglobin (Hb), platelets (Pl), leucocytes and creatinine for ...

Prostate cancer (PCa) is the most frequent cancer in men in the western world. PCa growth is highly dependent on androgens and androgen ablation is the cornerstone of current therapeutic approaches. μ-Crystalline (CRYM) is the main component of the kangaroohs eye’s lens. CRYM binds thyroid hormone (T3) in a NADPH dependent manner thereby sequestering it from being transcriptionally active in the nucleus. The role of CRYM in prostate cancer is largely unknown. This st...